Unexpected lateral-lithiation-induced alkylative ring opening of tetrahydrofurans in deep eutectic solvents: synthesis of functionalised primary alcohols.
نویسندگان
چکیده
o-Tolyl-substituted tetrahydrofurans undergo highly regioselective ring opening with the concomitant formation of new C-C bonds as the result of a lateral lithiation reaction. This reaction provides a new method for the synthesis of functionalised primary alcohols and can be run directly in protic eutectic mixtures as benign reaction media at 0 °C and under air, competitively with protonolysis.
منابع مشابه
Rhodium(II)-catalysed tandem aziridination and ring-opening: stereoselective synthesis of functionalised tetrahydrofurans.
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عنوان ژورنال:
- Chemical communications
دوره 51 46 شماره
صفحات -
تاریخ انتشار 2015